The Effects of HIV on the Regulation of IL-12 Family Cytokines, IL-12, IL-23, and IL-27 Production in Human Monocyte-derived Macrophages

The Effects of HIV on the Regulation of IL-12 Family Cytokines, IL-12, IL-23, and IL-27 Production in Human Monocyte-derived Macrophages

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IL-12 family cytokines IL-23 and IL-27 play an important role linking innate and adaptive immunity, and regulating T-cell responses. The production of IL-12, a structurally similar cytokine, is decreased in chronic HIV infection; therefore IL-23 and IL-27 may also be influenced by HIV infection. I h...

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Bibliographic Details
Main Author: O'Hara, Shifawn R.K.
Language:en
Published: 2012
Subjects:
HIV
monocyte
macrophage
cytokine
IL-23
IL-27
IL-12
LPS
signalling
PI3K
p38 MAPK
JNK MAPK
ERK MAPK
PKC
Online Access:http://hdl.handle.net/10393/23220

Internet

http://hdl.handle.net/10393/23220

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