The Amyotrophic Lateral Sclerosis 8 Mutant VAPB-P56S Causes a Nuclear Envelope and Nuclear Pore Defect

The Amyotrophic Lateral Sclerosis 8 Mutant VAPB-P56S Causes a Nuclear Envelope and Nuclear Pore Defect

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A P56S mutation in the VAPB MSP domain is linked to adult-onset amyotrophic lateral sclerosis 8. The objective of this study is to characterize the functional role of VAPB in transport of NE and NPC proteins from the ER to the NE. Over-expression of VAPB-P56S blocked the transport of nucleoporins (N...

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Bibliographic Details
Main Author: Chalhoub, Antonious
Language:en
Published: 2012
Subjects:
Nuclear
Nups
Amyotrophic Lateral Sclerosis
VAPB
ERGIC
gp210
nup214
emerin
Nuclear Envelope
Nuclear Pore Complex
Online Access:http://hdl.handle.net/10393/23191

Internet

http://hdl.handle.net/10393/23191

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