Identification of Novel Parkinson’s Disease Genes Involved in Parkin Mediated Mitophagy
Mitochondrial dysfunction has been implicated as one of the primary causes of Parkinson's disease (PD). The proteins PINK1, a serine-threonine kinase, and Parkin, an E3 ubiquitin ligase, are mutated in many genetic cases of PD. In healthy individuals, Parkin is recruited to damaged mitochondria...
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| Language: | en |
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2013
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| Online Access: | http://hdl.handle.net/10393/30222 |