ICAM-1 as a Novel Binding Partner for LPS to Mediate TLR4-Independent Cell Activation

Introduction: The mechanism of cell activation by LPS in the absence of surface Toll-like receptor 4 (TLR4) is unclear. We hypothesize that ICAM-1 binds LPS on the cell surface, mediating cell activation independent of TLR4. Methods: The interaction between murine ICAM-1 and LPS was measured in a b...

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Bibliographic Details
Main Author: Pabari, Reena
Other Authors: Zhang, Haibo
Language:en_ca
Published: 2009
Subjects:
Online Access:http://hdl.handle.net/1807/17702