Involvement of Reactive Metabolites in Idiosyncratic Drug Reactions
Idiosyncratic drug reactions (IDRs) represent a significant medical problem and pose a great challenge to drug development. Circumstantial evidence suggests that, in most cases, reactive metabolites of the drug are responsible. The major focus of this thesis is the identification of reactive metabol...
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| Language: | en_ca |
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2009
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| Online Access: | http://hdl.handle.net/1807/19289 |