Misfolding of Particular PrP and Susceptibility to Prion Infection
Pathogenesis of prion diseases in animals is associated with the misfolding of the cellular prion protein PrPC to the infectious form, PrPSc. We hypothesized that an animal’s susceptibility to prions is correlated with the propensity of an animal’s PrPC to adopt a β-sheet, PrPSc-like, conformation....
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| Language: | en_ca |
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2010
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| Online Access: | http://hdl.handle.net/1807/24589 |