Activation of Chloride Channels with the Anti-parasitic Agent Ivermectin Induces Membrane Hyperpolarization and Cell Death in Leukemia Cells
FDA-approved drugs with previously unrecognized anti-cancer activity could be rapidly repurposed for this new indication. We compiled a library of such off-patent drugs to screen four leukemia cell lines and identified the anti-parasitic agent ivermectin that induced cell death at low micromolar co...
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| Language: | en_ca |
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2010
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| Online Access: | http://hdl.handle.net/1807/24641 |