Characterization of the E3 Ubiquitin Ligase Pirh2
The p53 tumour suppressor gene is inactivated by mutation in over 50% of all human cancers. The p53 protein is activated and stabilized through several post-translational modifications in response to various stresses and promotes cell cycle arrest and apoptosis. Thus, regulation of p53 is critical f...
| Main Author: | |
|---|---|
| Other Authors: | |
| Language: | en_ca |
| Published: |
2010
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/1807/24889 |