Epigenetic Basis for Heterogeneity in VCAM-1 Gene Expression Patterns in Cytokine Activated Vascular Endothelium

Vascular cell adhesion molecule-1 (VCAM-1) is a cytokine-activated protein present on endothelial cells (ECs). Our laboratory has provided evidence that DNA methylation, a mark associated with gene silencing, is fundamental for regulating VCAM-1 expression. First, we showed that RNA polymerase II,...

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Bibliographic Details
Main Author: Jamal, Alisha Noorin
Other Authors: Marsden, Philip A.
Language:en_ca
Published: 2010
Subjects:
Online Access:http://hdl.handle.net/1807/25633