CYP2A6 and CYP2B6: Sources of Variation and their Role in Nicotine Metabolism
Nicotine is the primary substance in tobacco causing addiction. In humans the majority (70-80%) of nicotine is inactivated to cotinine in a reaction predominantly catalyzed by CYP2A6 (80-90%), with a minor possible role for CYP2B6. Substantial interindividual variability is observed in the rate of n...
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| Language: | en_ca |
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2010
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| Online Access: | http://hdl.handle.net/1807/25920 |