Molecular Mechanisms of the Cooperation between Rac1/1b GTPases and the Canonical Wnt Signaling Pathway in Colorectal Cancer

Aberrant activation of the canonical Wnt signaling pathway accounts for the vast majority of colorectal cancers. The Rac1 GTPase is overexpressed in colon cancer, and its splice variant, Rac1b, is preferentially expressed in colon tumours. Rac1 and Rac1b have both been previously shown to crosstal...

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Bibliographic Details
Main Author: Charames, George Shawn
Other Authors: Bapat, Bharati
Language:en_ca
Published: 2010
Subjects:
Wnt
Online Access:http://hdl.handle.net/1807/26158