The Mismatch Repair Pathway Functions Normally at a non-AID Target in Germinal Center B cells
Deficiency in Msh2, a component of the mismatch repair (MMR) system, leads to a ~10-fold increase in the mutation frequency in most tissues. By contrast, Msh2-deficiency in germinal center (GC) B cells decreases the mutation frequency at the IgH V-region, as a dU:dG mismatch produced by AID initiate...
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| Language: | en_ca |
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2011
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| Online Access: | http://hdl.handle.net/1807/30614 |