Identification and Characterization of the Interaction between VPS33B and SNAREs
VPS33B is a Sec1/Munc18 protein required for the biogenesis of α-granules in megakaryocytes, which give rise to platelets. Mutations in VPS33B cause arthrogryposis, renal dysfunction and cholestasis (ARC) syndrome. Platelets from ARC patients completely lack α-granules, causing a bleeding disorder...
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| Language: | en_ca |
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2011
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| Online Access: | http://hdl.handle.net/1807/31394 |