A Novel gene overexpression plasmid library and its application in mapping genetic networks by systematic dosage suppression
Increasing gene dosage provides a powerful means of probing gene function, as it tends to cause a gain-of-function effect due to increased gene activity. In the budding yeast, Saccharomyces cerevisiae, systematic gene overexpression studies have shown that in wild-type cells, overexpression of a sma...
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Language: | en_ca |
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2011
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Online Access: | http://hdl.handle.net/1807/32169 |