Proteolytic Processing of Nlrp1b in the FIIND Domain is Required for Inflammasome Activity

Proteolytic Processing of Nlrp1b in the FIIND Domain is Required for Inflammasome Activity

Show other versions (1)

Nlrp1b is a NOD-like receptor of the innate immune system that upon sensing of anthrax lethal toxin oliogmerizes and forms a protein scaffold that binds to and activates pro-caspase-1; this complex is called an inflammasome. Nlrp1b is highly polymorphic and different alleles display an all or none a...

Full description

Bibliographic Details
Main Author: Frew, Bradley
Other Authors: Mogridge, Jeremy
Language:en_ca
Published: 2012
Subjects:
Microbiology
Immunology
Nlrp1b
Nalp1b
Inflammasome
Anthrax
Lethal toxin
pyroptosis
caspase-1
NLR
Nlrp1
IL-1
NOD
CARD8
Cleaved
Cleavage
Proteolysis
Innate immune
Pattern recognition receptor
Inflammation
FIIND
CARD
0410
Online Access:http://hdl.handle.net/1807/32241

Internet

http://hdl.handle.net/1807/32241

Similar Items