Investigations into Tyrosine-mediated Hyperphosphorylation and Aggregation of Tau Protein via Ferrocene Bioconjugates
Tau, a microtubule associated protein, has been implicated in the formation of neurofibrillary tangles, a hallmark of Alzheimer’s disease.1 Resulting from the hyperphosphorylation of tyrosine, serine and threonine residues, protein kinases play an intricate role in the pathway of NFT formation.2 Whi...
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| Language: | en_ca |
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2012
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| Online Access: | http://hdl.handle.net/1807/33503 |