Thermodynamic and Spectroscopic Studies on the Molecular Interaction of Doxorubicin (DOX) with Negatively Charged Polymeric Nanoparticles

Thermodynamic and Spectroscopic Studies on the Molecular Interaction of Doxorubicin (DOX) with Negatively Charged Polymeric Nanoparticles

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The aim of this study was to investigate the molecular interactions of the anti-cancer drug Doxorubicin (DOX) with poly(methacrylic acid) grafted starch nanoparticles (PMAA-g-St). In order to fully understand the DOX/PMAA-g-St system, we conducted in-depth studies on DOX dimer dissociation and DOX/P...

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Bibliographic Details
Main Author: Gaurav, Raval
Other Authors: Heiko, Heerklotz
Language:en_ca
Published: 2012
Subjects:
Doxorubicin
Isothermal Titration Calorimetry
Dynamic Light Scattering
Drug/Polymer Interactions
Electrostatic Interactions
Specific binding
Mechanism of binding
effect of sodium chloride
effect of pH
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Online Access:http://hdl.handle.net/1807/33509

Internet

http://hdl.handle.net/1807/33509

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