High Glucose-induced ROS Production is Mediated by c-Src in Mesangial Cells

The pathogenesis of diabetic nephropathy (DN) remains incompletely understood. In previous studies, we observed the activation of Tyr kinase Src by high glucose (HG) and showed that Src is required for MAPK activation and synthesis of collagen IV in cultured rat mesangial cells (MCs). Reactive oxyge...

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Bibliographic Details
Main Author: Lee, Ken Wing Kin
Other Authors: Fantus, I. George
Language:en_ca
Published: 2012
Subjects:
Src
Online Access:http://hdl.handle.net/1807/33753