Hypertonicity Regulation of Cytochrome P450 CYP3A
Cytochrome P450 3A isozymes (CYP3A) metabolize approximately 50% of therapeutic drugs. It has recently been discovered that human CYP3A mRNA levels can be induced by hypertonicity; a physiological state not previously linked to its regulation. The osmosensitive transcription factor, Nuclear Factor o...
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| Language: | en_ca |
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2012
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| Online Access: | http://hdl.handle.net/1807/33963 |