The Role of the PTPN22 (Lyp/Pep) Phosphatase and its Disease-associated Variant in T-cell Signalling
The PTPN22 gene encoding the Lyp/Pep protein tyrosine phosphatase has recently been described as a negative regulator of T-cell receptor signalling. Little biological information is available on this protein, but a variant allele in this gene conferring a R620W change has been associated with rheum...
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| Language: | en_ca |
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2012
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| Online Access: | http://hdl.handle.net/1807/34810 |