Biochemical and Biophysical Studies of Human SUR1 NBD1, Rat SUR2A NBD2 and the Role of the C-terminal Extension in Rat SUR2A NBD1

Biochemical and Biophysical Studies of Human SUR1 NBD1, Rat SUR2A NBD2 and the Role of the C-terminal Extension in Rat SUR2A NBD1

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SUR2A-mediated regulation of KATP channels is affected by residues belonging to the C terminus of the first nucleotide binding domain (NBD1). We studied the C-terminal region of NBD1 by comparing experiments using NBD1 S615-D914 and NBD1 S615-K972 constructs to studies of NBD1 S615-L933 also perform...

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Bibliographic Details
Main Author: Alvarez, Claudia Paola
Other Authors: Voula, Kanelis
Language:en_ca
Published: 2013
Subjects:
rSUR2A NBD1
hSUR1 NBD1
rSUR2A NBD2
NBDs
potassium channel
KATP channel
NBD1 phosphorylation
C-terminal extension
Tryptophan quenching
Thermal denaturation
NMR
Regulation of NBD1
Acrylamide quenching
Iodide quenching
Fluorescence
Circular dichroism
NBD1 C-terminal tail
MgATP binding
0487
Online Access:http://hdl.handle.net/1807/35107

Internet

http://hdl.handle.net/1807/35107

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