Novel Intrinsic and Extrinsic Approaches to Selectively Regulate Glycosphingolipid Metabolism

Novel Intrinsic and Extrinsic Approaches to Selectively Regulate Glycosphingolipid Metabolism

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Glycosphingolipid (GSL) metabolism is a complex process involving proteins and enzymes at distinct locations within the cell. Mammalian GSLs are typically based on glucose or galactose, forming glucosylceramide (GlcCer) and galactosylceramide (GalCer). Most GSLs are derived from GlcCer, which is s...

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Bibliographic Details
Main Author: Kamani, Mustafa
Other Authors: Lingwood, Clifford A.
Language:en_ca
Published: 2013
Subjects:
Sphingolipids
Metabolism
Lysosomal storage disorders
adamantane
Glucosylceramide
Lactosylceramide
P-glycoprotein
MDR1
Gaucher disease
Fabry disease
siRNA
Gb2 galabiosylceramide
Glycolipids
Inhibitors
Knockout mouse
Crossbreeding
Glucosylceramide synthase
Lactosylceramide synthase
Ganglioside
Globo-series
Gb3 synthase
pharmacological chaperone
Glucocerebrosidase
Substrate reduction therapy
ATP8B1
Cholesterol
ABC Transporters
P-type ATPase
Flippase
FAPP2
GLTP
Glycosyltransferase
Glycolipid analogues
ERAD
ABCB1
knockdown
GM3 and EGFR
GM3 and insulin receptor
Glycolipid synthesis
Glycolipid metabolism
enzyme enhancement therapy
0487
0307
0491
0379
0306
Online Access:http://hdl.handle.net/1807/35860

Internet

http://hdl.handle.net/1807/35860

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