Structural and Mechanistic Insights into RAF Kinase Regulation by the KSR/CNK/HYP Complex
The RAS/RAF/MEK/ERK pathway is the prototypical cellular signal transduction cascade and has been the focus of intense scrutiny over the last two decades. As a mitogenic pathway, its activation is a potent driver of cellular growth and survival, and its deregulation underlies many cancers. While RAS...
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Language: | en_ca |
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2012
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Online Access: | http://hdl.handle.net/1807/42552 |