The Impact of ROS Scavenging on NMDA and AMPA Receptor Whole Cell Currents in Pyramidal Neurons of the Anoxia Tolerant Western Painted Turtle

The Impact of ROS Scavenging on NMDA and AMPA Receptor Whole Cell Currents in Pyramidal Neurons of the Anoxia Tolerant Western Painted Turtle

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Extended periods of oxygen deprivation cause brain death in mammals but the western painted turtle overwinters in anoxic mud for months without damage. Neural protection is achieved through decreases in the whole cell currents of N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepro...

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Bibliographic Details
Main Author: Dukoff, David
Other Authors: Buck, Leslie
Language:en_ca
Published: 2013
Subjects:
anoxia
reactive oxidative speecies
NMDAR
AMPAR
western painted turtle
mitochondria
ATP-sensitive potassium channels
calcium
hydrogen peroxide
N-acetylcysteine
N-2-mercaptopropionylglycine
NMDAR redox site
electrophysiological patch clamping
fluorescent microscopy
0379
Online Access:http://hdl.handle.net/1807/42826

Internet

http://hdl.handle.net/1807/42826

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