Lipid Accumulation in CD11c-expressing Intimal Myeloid Cells Induces Chemokine Production Required for Leukocyte Recruitment to Early Atherosclerotic Lesions

Monocyte recruitment promotes the accumulation of myeloid foam cells in early atherosclerotic plaques. However, initial foam cells form prior to increased monocyte recruitment in hypercholesterolemic Ldlr-/- mice. These initial foam cells are derived from myeloid cells residing in the normal intim...

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Bibliographic Details
Main Author: Siu, Allan
Other Authors: Cybulsky, Myron
Language:en_ca
Published: 2013
Subjects:
Online Access:http://hdl.handle.net/1807/42935