Comparative Interactome Investigation of γ-secretase Complex in Alzheimer’s Disease
γ-Secretase plays a pivotal role in the production of neurotoxic amyloid β-peptide (Aβ), the principal component of amyloid plaques present in Alzheimer’s disease. It consists of a core complex of presenilin (PS), nicastrin, anterior pharynx-defective 1 (Aph-1), and presenilin enhancer 2 (Pen-2) pro...
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| Language: | en_ca |
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2012
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| Online Access: | http://hdl.handle.net/1807/43389 |