Hsp70 Protects Against Peroxynitrite-Induced Inactivation of SERCA2a by Preventing Protein Oxidation and Aggregation
The purpose of this study was to examine the effects of exogenous peroxynitrite (ONOO-) on the cardiac isoform of the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2a) and to determine if overexpression of heat shock protein 70 (Hsp70) could protect SERCA2a function. To characterize the interaction...
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| Language: | en |
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2008
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| Online Access: | http://hdl.handle.net/10012/3993 |