Downstream Bioprocess Development for a Scalable Production of Pharmaceutical-grade Plasmid DNA
The potential application of a hydrogel-based strong anion-exchange (Q) membrane to purify plasmid DNAs was evaluated. The maximum binding capacity of plasmid DNA was estimated to be 12.4 mg/ml of membrane volume with a plasmid DNA recovery of ~ 90%, which is superior to other commercially available...
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| Language: | en |
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2011
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| Online Access: | http://hdl.handle.net/10012/6215 |