Characterization of Dbf4 structure and function in Saccharomyces cerevisiae DNA replication and checkpoint responses.
The Dbf4/Cdc7 kinase complex is required for the initiation of DNA replication and promotes this by acting upon members of the Mcm2-7 helicase. In addition to its role in replication, Dbf4/Cdc7 is a target of the S-phase checkpoint response through the Rad53 checkpoint kinase. In the budding yeast S...
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| Language: | en |
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2014
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| Online Access: | http://hdl.handle.net/10012/8279 |