The cancer chemo-preventive properties of vitamin D are due, at least in part, to the transcriptional regulation of genes implicated in cell cycle, DNA replication and Apoptosis, and activation of FoxO3a transcription factor
Vitamin D is produced in the skin or obtained from limited dietary sources. Two sequential hydroxylation reactions in the liver and kidney produce the active form of the hormone, 1,25-(OH)2D3, which binds to and activates VDR to regulate gene expression (genomic effects) or to VDRmem or MARRS to tri...
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| Format: | Others |
| Language: | en |
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McGill University
2012
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| Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107691 |