The cancer chemo-preventive properties of vitamin D are due, at least in part, to the transcriptional regulation of genes implicated in cell cycle, DNA replication and Apoptosis, and activation of FoxO3a transcription factor

Vitamin D is produced in the skin or obtained from limited dietary sources. Two sequential hydroxylation reactions in the liver and kidney produce the active form of the hormone, 1,25-(OH)2D3, which binds to and activates VDR to regulate gene expression (genomic effects) or to VDRmem or MARRS to tri...

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Bibliographic Details
Main Author: Dimitrov, Vassil
Other Authors: John H White (Internal/Supervisor)
Format: Others
Language:en
Published: McGill University 2012
Subjects:
Online Access:http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107691