Suppressive activity of CD4+Foxp3+ regulatory T cells in an animal model of spontaneous CD8+ T cell-mediated demyelinating disease
Dr. Fournier's laboratory has generated a mouse strain (L31 mice) that spontaneously develops a CD8+ T cell-mediated demyelinating disease in the central nervous system. In this model of dysregulated costimulation, CD4+ T cells have a regulatory role. A subset of CD4+ regulatory T cells that ex...
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| Format: | Others |
| Language: | en |
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McGill University
2012
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| Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110761 |