E3 ubiquitin ligase Hrd1 mediates the retrotranslocation of human Prion protein
Prion diseases are fatal neurodegenerative disorders. Ubiquitously expressed Prion protein (PrP) is found at the cell surface and is abundant in brain. However, a small proportion of PrP is found in the cytosol (CyPrP), arising from the ER-associated degradation (ERAD) pathway. CyPrP protects agains...
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| Format: | Others |
| Language: | en |
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McGill University
2014
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| Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121158 |