The effect of the polyglutamine expansion of the Androgen Receptor on the ubiquitin proteasome system for protein degradation
The Androgen Receptor (AR; Xq11.2-q12) is a well-characterized X-linked gene. The AR protein functions primarily as a steroid-activated transcription factor. A structural feature of the AR transactivational domain (TAD) called the polyglutamine tract will be the primary focus of this thesis. The...
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| Format: | Others |
| Language: | en |
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McGill University
2008
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| Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21918 |