The effect of the polyglutamine expansion of the Androgen Receptor on the ubiquitin proteasome system for protein degradation
The Androgen Receptor (AR; Xq11.2-q12) is a well-characterized X-linked gene. The AR protein functions primarily as a steroid-activated transcription factor. A structural feature of the AR transactivational domain (TAD) called the polyglutamine tract will be the primary focus of this thesis. The...
Main Author: | Scanlon, Thomas Carr |
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Other Authors: | Mark Anthony Trifiro (Supervisor) |
Format: | Others |
Language: | en |
Published: |
McGill University
2008
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Subjects: | |
Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21918 |
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