Germline transmission of mitochondrial DNA in the mouse

In mammals, mitochondria and mitochondrial DNA (mtDNA) are transmitted through the female germline. Mature oocytes contain nearly 200,000 copies of mtDNA, organized at 1-2 copies per organelle. Despite the high genome copy number, mtDNA sequence variants are observed to segregate rapidly between g...

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Bibliographic Details
Main Author: Wai, Timothy
Other Authors: Eric Alan Shoubridge (Supervisor)
Format: Others
Language:en
Published: McGill University 2009
Subjects:
Online Access:http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40735