Characterization of the novel arsenical darinaparsin (ZIO- 101, S-dimethylarsino-glutathione) as a more potent inducer of oxidative stress and apoptosis than arsenic trioxide in acute promyelocytic leukemia
Arsenic trioxide (As2O3) is an effective treatment strategy for acute promyelocytic leukemia (APL), as sensitivity to As2O3 may correlate with the induction of oxidative stress. However, the use of As2O3 in other malignancies is limited at clinically achievable doses. To expand the clinical potentia...
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| Format: | Others |
| Language: | en |
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McGill University
2009
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| Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40780 |