The effects of IGF-I overexpression on somatic growth and bone deficiency caused by growth hormone receptor knockout in mice
Growth hormone (GH) and IGF-I are essential for somatic growth, while exerting distinct effects on energy homeostasis. GH controls IGF-I production, but whether IGF-I exclusively mediates the growth effect is still debated. To explore the in vivo interactions of GH and IGF-I, we crossed IGF...
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| Format: | Others |
| Language: | en |
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McGill University
2009
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| Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66804 |