Neuroprotective properties of Hsp90 inhibitor NXD30001 in a primary culture model of amyotrophic lateral sclerosis
Protein misfolding and aggregation are important features in the pathogenesis of amyotrophic lateral sclerosis (ALS). Upregulation of protein chaperones (heat shock proteins; HSPs) protects against cellular stress, as well as in models of ALS. Treatment with Hsp90 inhibitors upregulates multiple HSP...
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| Format: | Others |
| Language: | en |
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McGill University
2011
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| Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96932 |