Study of Complex RNA Function Modulated by Small Molecules: The Development of RNA Directed Small Molecule Library and Probing the S-Adenosyl Methionine Discrimination between On and Off Conformational States of the SAM-I Riboswitch.
RNA recently remained unexploited and is now drawing interest as a potential drug target. The methodology and available drug libraries for RNA targeting/screening are in rudimentary stages. The interactions made by ligands with RNA can be explored for RNA based drug development. The dissertation is...
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| Format: | Others |
| Language: | en |
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LSU
2011
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| Online Access: | http://etd.lsu.edu/docs/available/etd-11082011-165455/ |