Targeted disruption of the insulin-like growth factor binding protein-3 gene in mouse embryonic stem cells
Insulin-like growth factors (IGFs) play important functions in cell proliferation, differentiation and metabolism. The biological actions of IGFs are mediated through binding to the specific receptor-IGF-I receptor. However, in the circulation IGFs are associated with their binding proteins: the ins...
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| Language: | en_US |
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2007
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| Online Access: | http://hdl.handle.net/1993/1140 |