Computational modeling of Ca2+ and Zn2+ competition in Calbindin D28k, implications for altering calcium homeostasis
Neurodegeneration in Alzheimer's disease is characterised by multiple pathologies including disrupted calcium homeostasis and elevated Zn2+ levels. Calbindin D28k (CB-D28k), which buffers Ca2+ and can bind Zn2+, was suspected to be involved in these abnormalities. The PDB structure of this EF-h...
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2013
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| Online Access: | http://hdl.handle.net/1993/14425 |