Enhancement of antitumour activity and structure-activity study of bioreductive agents
DT-diaphorase is a two-electron reducing enzyme that activates the bioreductive antitumour agent, mitomycin C (MMC). Cell lines having elevated levels of DT-diaphorase are generally more sensitive to MMC. This study demonstrates that induction of DT-diaphorase can increase the cytotoxic activity of...
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| Language: | en_US |
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2007
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| Online Access: | http://hdl.handle.net/1993/1601 |