Progress towards hypoxia-activated SN-38: the potential to target hypoxic tumors
Solid tumors are commonly subject to hypoxia. Hypoxic cancer cells have undesirable properties such as a high tendency to metastasize and resistance to chemotherapy and radiotherapy. Hypoxia-inducible factors (HIFs) respond to the changes in oxygen levels, orchestrating the transcription of many pro...
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Bentham Science
2016
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| Online Access: | http://hdl.handle.net/1993/31591 |