Mechanisms of Sirtuin-2 (SIRT2) enhancement of mitochondrial function and axon regeneration in control and diabetic adult sensory neurons
Rationale and hypothesis: Diabetic sensory neuropathy involves a distal dying-back of nerve fibers. Neuronal mitochondrial function is impaired in diabetes and Sirtuin 2 (SIRT2) is a sensor of redox state that regulates cellular bioenergetics. The role of SIRT2 in regulating the phenotype of adult s...
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2016
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| Online Access: | http://hdl.handle.net/1993/31829 |