Effect of human equilibrative nucleoside transporter 1 (hENT1) and ecto-5' nucleotidase (eN) in adenosine formation by neurons and astrocytes under ischemic conditions.

Effect of human equilibrative nucleoside transporter 1 (hENT1) and ecto-5' nucleotidase (eN) in adenosine formation by neurons and astrocytes under ischemic conditions.

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Adenosine (ADO) is an endogenous neuroprotectant. Under ischemic conditions ADO levels rise in the brain up to 100-fold. ADO in the brain is dependent on the movement across cell membranes by equilibrative nucleoside transporters (ENT) or produced from membrane bound ecto-5’ nucleotidase (eN). W...

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Bibliographic Details
Main Author: Chu, Stephanie S.T.Y.
Other Authors: Parkinson, Fiona (Pharmacology & Therapeutics)
Published: 2012
Subjects:
Adenosine
human equilibrative nucleoside transporter (hENT1)
ecto 5' nucleotidase (CD73)
cerebral ischemia
NMDA
neuron
astrocyte
cell culture
oxygen-glucose deprivation
Online Access:http://hdl.handle.net/1993/8353

Internet

http://hdl.handle.net/1993/8353

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