Intranasal delivery of pGDNF nanoparticles for Parkinson's disease

Parkinson's disease (PD) is a progressive neurodegenerative disorder that primarily affects the dopaminergic A9 nigrostriatal tract. For dopamine neurons specifically, glial cell-derived neurotrophic factor (GDNF) has been shown to promote their survival and proliferation both in culture and in...

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Online Access:http://hdl.handle.net/2047/d20003327