Contribution of distal residues in Escherichia coli DinB and human DNA polymerase κ to their activities in translesion synthesis

DNA is constantly threatened by damage from endogenous and exogenous sources. Replicative DNA polymerases are typically unable to replicate damaged DNA, but specialized DNA polymerases in the Y family possess this ability. Escherichia coli has two Y family polymerases that are specialized to bypass...

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Online Access:http://hdl.handle.net/2047/D20413927