Transactivational activity of the tumor suppressor protein p53 is dependent on thioredoxin reductase activity in mammalian cells
Reporter gene transactivation by human p53 is inhibited in budding yeast lacking the TRR1 gene encoding thioredoxin reductase. Thioredoxin reductase specifically catalyzes the NADPH-dependent reduction of thioredoxin. Thioredoxin provides a source of electrons for disulfide reduction in various cell...
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| Language: | en_US |
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2012
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| Online Access: | http://hdl.handle.net/1957/30498 |