Multifaceted Mechanism of Amicoumacin A Inhibition of Bacterial Translation

Amicoumacin A (Ami) halts bacterial growth by inhibiting the ribosome during translation. The Ami binding site locates in the vicinity of the E-site codon of mRNA. However, Ami does not clash with mRNA, rather stabilizes it, which is relatively unusual and implies a unique way of translation inhibit...

Full description

Bibliographic Details
Main Authors: Maksimova, Elena M., Vinogradova, Daria S., Osterman, Ilya A., Kasatsky, Pavel S., Nikonov, Oleg S., Milón, Pohl, Dontsova, Olga A., Sergiev, Petr V., Paleskava, Alena, Konevega, Andrey L.
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
Online Access:http://hdl.handle.net/10757/655822