Evaluation of Extracellular Matrix Composition and Rheology as Determinants of Growth, Invasion, and Response to Photodynamic Therapy in 3D Cell Culture Models of Pancreatic Ductal Adenocarcinoma
<p> Pancreatic ductal adenocarcinoma (PDAC) is a notoriously lethal disease characterized by prominent stromal involvement, which plays complex roles in regulating tumor growth and therapeutic response. The extracellular matrix (ECM)-rich stroma has been implicated as a barrier to drug penetra...
| Main Author: | |
|---|---|
| Language: | EN |
| Published: |
University of Massachusetts Boston
2018
|
| Subjects: | |
| Online Access: | http://pqdtopen.proquest.com/#viewpdf?dispub=10682145 |